Vitamin A is essential to support growth and help combat infections in childhood. Clinical trials have demonstrated that VAS is a life-saving intervention that is vital to reduce the risk of child mortality, morbidity, and malnutrition in countries with high levels of vitamin A deficiency (VAD). Although there is currently no evidence on the effectiveness of high-dose VAS for the treatment of COVID-19 or the reduction in severity of the specific illness it causes, VAS is especially important for vulnerable children during an infectious disease outbreak when access to health services is limited.